Dutasteride-13C6

Dutasteride-13C6 is intended for use as an internal standard for the quantification of dutasteride (Cay-15956) by GC- or LC-MS. Dutasteride is a dual inhibitor of 5alpha-reductase types I and II (Kis = 6 and 7 nM, respectively). Its inhibition is time-dependent with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively. Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres. It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer. Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.Formal Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl-1,2,3,4,5,6-13C6)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide. CAS Number: 1217685-27-2. Molecular Formula: C21[13C]6H30F6N2O2. Formula Weight: 534.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(N[13C]5=[13C](C(F)(F)F)[13CH]=[13CH][13C](C(F)(F)F)=[13CH]5)=O)([H])N1. InChi Code: InChI=1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1/i3+1,5+1,13+1,14+1,18+1,20+1. InChi Key: JWJOTENAMICLJG-JADBXJRRSA-N.