DSPE-PEG(2000) Maleimide

DSPE-PEG(2000) maleimide is a PEGylated derivative of 1,2-distearoyl-rac-3-PE (DSPE). It has been used in the synthesis of lipid nanoparticles (LNPs) for the delivery of siRNA or small molecule anticancer agents in vitro and in vivo. LNPs containing DSPE-PEG(2000) maleimide and encapsulating siRNAs targeting mRNA encoding p53 and K-RAS induce tumor regression in a PANC-1 pancreatic ductal adenocarcinoma mouse xenograft model.Formal Name: alpha-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-omega-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl). CAS Number: 185844-12-6. Synonyms: 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-PEG-2000 Maleimide, 1,2-Distearoyl-sn-glycero-3-Phosphatidylethanolamine-N-[maleimide(polyethylene glycol)-2000], 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000], 1,2-DSPE-PEG(2000)-Mal, 1,2-DSPE-PEG(2000) Maleimide, DSPE-PEG-Mal, 18:0/18:0-PE-PEG(2000) Maleimide, PE-18:0/18:0-PEG(2000) Maleimide. Molecular Formula: (C2H4O)nC51H92N3O13P. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Sparingly soluble: 1-10 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml, Water: Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(NCCOP(O)(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCN1C(C=CC1=O)=O)=O.