Dehydrocholic Acid

Dehydrocholic acid is a synthetic bile acid and a derivative of cholic acid (Cay-20250). It increases bile flow by 2.7-fold and decreases biliary levels of phospholipids, cholesterol, and bilirubin in conscious dogs when administered at a dose of 50 mg/kg. Dehydrocholic acid (1 µmol/min/0.1 kg) increases bile flow by 253% and decreases the secretion rate of phospholipids and cholesterol by 64 and 94%, respectively, in rats when infused intravenously at a dose of 2 µmol/min/0.1 kg.Formal Name: (5beta)-3,7,12-trioxo-cholan-24-oic acid. CAS Number: 81-23-2. Synonyms: NSC 8796, 3,7,12-Triketocholanic Acid, Triketocholanoic Acid. Molecular Formula: C24H34O5. Formula Weight: 402.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]([C@]21C)([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O. InChi Code: InChI=1S/C24H34O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-14,16-18,22H,4-12H2,1-3H3,(H,28,29)/t13-,14+,16-,17+,18+,22+,23+,24-/m1/s1. InChi Key: OHXPGWPVLFPUSM-KLRNGDHRSA-N.