CP-LC-1447

Lipid CP-LC-1447 is an ionizable cationic amino lipid derived from homocysteine, a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA, cRNA and saRNA) in vivo. Moreover, using a typical LNP formulation (IL/Ch/DOPE/PEG: 50/38.5/10/1.5), it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives through IV injection, with no signs of toxicity.Formal Name: dioctyl 3,3'-((8-((1-((2-(1H-imidazol-1-yl)ethyl)amino)-1-oxo-4-((3-oxo-3-(tridecyloxy)propyl)thio)butan-2-yl)amino)-8-oxooctane-1,3-diyl)bis(sulfanediyl))dipropionate. Molecular Formula: C55H100N4O8S3. Formula Weight: 1041.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: O=C(NCCN1C=CN=C1)C(CCSCCC(OCCCCCCCCCCCCC)=O)NC(CCCCC(CCSCCC(OCCCCCCCC)=O)SCCC(OCCCCCCCC)=O)=O. InChi Code: InChI=1S/C55H100N4O8S3/c1-4-7-10-13-16-17-18-19-20-23-28-41-66-53(62)34-46-69-44-32-50(55(64)57-37-39-59-38-36-56-48-59)58-51(60)30-25-24-29-49(70-47-35-54(63)67-42-27-22-15-12-9-6-3)31-43-68-45-33-52(61)65-40-26-21-14-11-8-5-2/h36,38,48-50H,4-35,37,39-47H2,1-3H3,(H,57,64)(H,58,60). InChi Key: FHVDYXCHVWHIHK-UHFFFAOYSA-N.