Cortisone Acetate

Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties. It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing. It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%. Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.Formal Name: 21-(acetyloxy)-17-hydroxy-pregn-4-ene-3,11,20-trione. CAS Number: 50-04-4. Synonyms: Cortisone 21-acetate, NSC 49420. Molecular Formula: C23H30O6. Formula Weight: 402.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 20 mg/ml, Ethanol: 2 mg/ml. lambdamax: 238 nm. SMILES: [H][C@]12[C@@]([C@@](CC[C@]3(O)C(COC(C)=O)=O)([H])[C@]3(C)CC2=O)([H])CCC4=CC(CC[C@@]41C)=O. InChi Code: InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1. InChi Key: ITRJWOMZKQRYTA-RFZYENFJSA-N.