Chonglou Saponin VII

Chonglou saponin VII is a steroid saponin that has been found in P. polyphylla and has anticancer activities. It inhibits the proliferation of HepG2 cells and HepG2 cells resistant to doxorubicin (HepG2/ADR cells) when used at concentrations of 1.98 and 2.97 µM. Chonglou saponin VII (1.98 µM) reduces ADR resistance in HepG2/ADR cells when administered in combination with ADR, an effect that is enhanced by the addition of the PI3K inhibitor LY294002 (Cay-70920) and the p38 MAPK inhibitor SB203580. It also inhibits the proliferation of MDA-MB-231, MDA-MB-436, and MCF-7 breast cancer cells (IC50s = 3.16, 3.45, and 2.86 µM, respectively). It induces apoptosis and autophagosome formation in the same cells. Chonglou saponin VII (1.5 mg/kg) induces intratumoral autophagy and reduces tumor growth in an MDA-MB-231 mouse xenograft model.Formal Name: (3beta,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-6-deoxy-alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside. CAS Number: 68124-04-9. Synonyms: Paris Saponin VII, PS VII. Molecular Formula: C51H82O21. Formula Weight: 1031.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: [H][C@]1(C[C@@]2(O[C@]3([C@H]([C@@]24O)C)OC[C@@H](CC3)C)[H])[C@@]5(CC=C6C[C@@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@@H]([C@@H](CO)O7)O[C@@H]9O[C@H]([C@@H]([C@H]([C@H]9O)O)O[C@@H]%10O[C@H]([C@@H]([C@H]([C@H]%10O)O)O)C)C)CC[C@@]6([C@@](CC[C@@]14C)5[H])C)[H]. InChi Code: InChI=1S/C51H82O21/c1-20-10-15-50(63-19-20)24(5)51(62)31(72-50)17-29-27-9-8-25-16-26(11-13-48(25,6)28(27)12-14-49(29,51)7)67-47-43(71-45-38(59)35(56)33(54)22(3)65-45)40(61)42(30(18-52)68-47)70-46-39(60)36(57)41(23(4)66-46)69-44-37(58)34(55)32(53)21(2)64-44/h8,20-24,26-47,52-62H,9-19H2,1-7H3/t20-,21+,22+,23+,24-,26+,27-,28+,29+,30-,31+,32+,33+,34-,35-,36+,37-,38-,39-,40+,41+,42-,43-,44+,45+,46+,47-,48+,49+,50-,51-/m1/s1. InChi Key: FBFJAXUYHGSVFN-IYUYFXHASA-N. Origin: Plant/Paris polyphylla.