Cholesteryl Linoleate

Cholesteryl linoleate is a pro-atherogenic cholesterol ester. It has been found in the plasma membrane of macrophages as a component of LDL, where it undergoes oxidation to form cholesteryl linoleate hydroperoxides (Cay-48001). Cholesteryl linoleate levels are increased in apoB-lipoproteins and positively correlated with hepatic cholesterol levels and the number of atherosclerotic lesions in transgenic mice overexpressing human ABCA1. Lipoprotein levels of cholesteryl linoleate are increased and associated with lipid radical formation in patients with beta-thalassemia.Formal Name: cholest-5-en-3beta-ol, 3-[(9Z,12Z)-9,12-octadecadienoate]. CAS Number: 604-33-1. Synonyms: 18:2(9,12) CE, CE(18:2), 18:2(9,12) Cholesterol ester, Cholesterol Linoleate, Linoleic Acid cholesteryl ester, NSC 18183. Molecular Formula: C45H76O2. Formula Weight: 649.1. Purity: >98%. Formulation: (Request formulation change), A waxy crystal. Solubility: Chloroform: 10 mg/ml. lambdamax: 232 nm. SMILES: C[C@]12C(C[C@@H](OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@@H](CCCC(C)C)C)[H]. InChi Code: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1. InChi Key: NAACPBBQTFFYQB-LJAITQKLSA-N. Side Chain Carbon Sum: 18:2.