CAY10410

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARgamma ligand activity and resistance to metabolism. 15-deoxy-Delta12,14-PGJ2 has been shown to be a potent ligand for PPARgamma. Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Delta12-PGJ2 occurs via glutathione addition across the alpha,beta unsaturated enone. CAY10410 was designed as an analog of the PPARgamma-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.Formal Name: 11-oxo-prosta-5Z,12E,14Z-trien-1-oic acid. CAS Number: 596104-94-8. Synonyms: 9,10-dihydro-15-deoxy-Delta12,14-PGJ2, 9,10-dihydro-15-deoxy-Delta12,14-Prostaglandin J2. Molecular Formula: C20H30O3. Formula Weight: 318.5. Purity: >98% (mixture of isomers). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: -: -, DMF: 100 mg/ml, DMSO: 20 mg/ml, Ethanol: 75 mg/ml, PBS (7.2): 2.7 mg/ml. lambdamax: 293 nm. SMILES: O=C1/C([C@@H](C/C=C\CCCC(O)=O)CC1)=C/C=C\CCCCC. InChi Code: InChI=1S/C20H30O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,17H,2-5,8,11-12,14-16H2,1H3,(H,22,23)/b9-7-,10-6-,18-13+/t17-/m0/s1. InChi Key: AFBJLDUEEOOVHL-WKELIDJCSA-N.