C16 Glucosylceramide-d3 (d18:1/16:0-d3)

C16 Glucosylceramide-d3 is intended for use as an internal standard for the quantification of C16 glucosylceramide by GC- or LC-MS. C16 glucosylceramide is an endogenous bioactive sphingolipid. It is a precursor in the synthesis of C16 lactosylceramide (Cay-24352) that is formed via metabolism of C16 ceramide (Cay-10681) by glucosylceramide synthase. Inhalation of C16 glucosylceramide reduces lung colonization by P. aeruginosa and increases survival in a mouse model of cystic fibrosis. C16 Glucosylceramide levels are elevated in the plasma of Parkinson's disease patients with cognitive impairments. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1533]Formal Name: N-((2S,3R,E)-3-hydroxy-1-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)octadec-4-en-2-yl)hexadecanamide-d3. Synonyms: N-omega-CD3-Hexadecanoyl-glucopsychosine, GluCer(d18:1/16:0-d3), Glucosylceramide-d3 (d18:1/16:0-d3). Molecular Formula: C40H74D3NO8. Formula Weight: 703.1. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (2:1): Soluble. SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O. InChi Code: InChI=1S/C40H77NO8/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(43)33(32-48-40-39(47)38(46)37(45)35(31-42)49-40)41-36(44)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,33-35,37-40,42-43,45-47H,3-26,28,30-32H2,1-2H3,(H,41,44)/b29-27+/t33-,34+,35+,37+,38-,39+,40+/m0/s1/i2D3. InChi Key: VJLLLMIZEJJZTE-LKPYDFSUSA-N.