Bromfenac (sodium salt)

Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2, IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM). It inhibits prostaglandin E2 (PGE2, Cay-14010) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks. Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.Formal Name: 2-amino-3-(4-bromobenzoyl)-benzeneacetic acid, monosodium salt. CAS Number: 91714-93-1. Synonyms: AHR 10282B. Molecular Formula: C15H11BrNO3 . Na. Formula Weight: 356.2. Purity: >99%. Formulation: (Request formulation change), A powder. Solubility: DMSO: 100 mM, Ethanol: 5 mM, Water: 100 mM. SMILES: BrC1=CC=C(C(C2=CC=CC(CC([O-])=O)=C2N)=O)C=C1.[Na+]. InChi Code: InChI=1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19,/h1-7H,8,17H2,(H,18,19),/q,+1/p-1. InChi Key: HZFGMQJYAFHESD-UHFFFAOYSA-M.