Ascorbyl Tetraisopalmitate

Ascorbyl tetraisopalmitate is a lipophilic derivative of vitamin C (L-ascorbic acid, Cay-14656). It protects against UVB-, hydrogen peroxide-, or tert-butyl hydroperoxide-induced decreases in cell viability in HaCaT keratinocytes when used at a concentration of 100 µM. Ascorbyl tetraisopalmitate (20 µM) decreases IL-1alpha and prostaglandin E2 (PGE2, Cay-14010) production in unstimulated and UVB-stimulated HaCaT keratinocytes. Topical application of ascorbyl tetraisopalmitate (1%) increases viable epidermis thickness, stratum corneum water content, and skin smoothness and decreases skin roughness in hairless mice. Formulations containing ascorbyl tetraisopalmitate have been used in cosmetic products as skin-lightening agents.Formal Name: 2,3,5,6-tetrakis(2-hexyldecanoate) L-ascorbic acid. CAS Number: 183476-82-6. Synonyms: tetra-isopalmitoyl Ascorbic Acid, IPAA, Tetrahexyldecyl Ascorbate, VC-IP, Vitamin C-isopalmityl tetraester. Molecular Formula: C70H128O10. Formula Weight: 1129.8. Purity: >95%. Formulation: (Request formulation change), A neat liquid. Solubility: DMF: 2 mg/ml, DMSO: insol, Ethanol: 10 mg/ml, PBS (pH 7.2): insol. lambdamax: 223 nm. SMILES: CCCCCCC(CCCCCCCC)C(OC[C@H](OC(C(CCCCCCCC)CCCCCC)=O)[C@@]1([H])OC(C(OC(C(CCCCCCCC)CCCCCC)=O)=C1OC(C(CCCCCC)CCCCCCCC)=O)=O)=O. InChi Code: InChI=1S/C70H128O10/c1-9-17-25-33-37-45-50-58(49-41-29-21-13-5)66(71)76-57-62(77-67(72)59(51-42-30-22-14-6)54-46-38-34-26-18-10-2)63-64(79-68(73)60(52-43-31-23-15-7)55-47-39-35-27-19-11-3)65(70(75)78-63)80-69(74)61(53-44-32-24-16-8)56-48-40-36-28-20-12-4/h58-63H,9-57H2,1-8H3/t58?,59?,60?,61?,62-,63+/m0/s1. InChi Key: OEWBEINAQKIQLZ-CMRBMDBWSA-N.