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Anthraflavic acid is a polyketide synthase-derived anthraquinone that has been found in Rhei... more
Product information "Anthraflavic Acid"
Anthraflavic acid is a polyketide synthase-derived anthraquinone that has been found in Rhei Rhizoma and has diverse biological activities. It inhibits alpha-amylase in a cell-free assay (IC50 = 198.3 nM) and cytochrome P450 activity induced by a mixture of polychlorinated biphenyls (PCBs) in rat hepatic microsomes. Anthraflavic acid binds to estrogen receptor alpha (ERalpha) and ERbeta (Kis = 0.31 and 0.69 µM, respectively). It is cytotoxic against a panel of six breast cancer cell lines (IC50s = 156-241 µg/ml). Anthraflavic acid (50 µM) inhibits mutagenicity induced by the carcinogen 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) in the Ames test using S. typhimurium. Topical application of anthraflavic acid (3 µmol/animal) reduces the number of tumors per mouse and the number of mice with tumors in a model of two-stage carcinogenesis initiated by 7,12-dimethylbenz[a]anthracene (DMBA, Cay-30383) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA, Cay-10008014). Anthraflavic acid has been used as an anolyte in redox flow batteries.Formal Name: 2,6-dihydroxy-9,10-anthracenedione. CAS Number: 84-60-6. Synonyms: 2,6-Dihydroxyanthraquinone, 2,6-DHAQ, NSC 33531. Molecular Formula: C14H8O4. Formula Weight: 240.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble, Water: Slightly soluble. SMILES: O=C1C2=CC=C(C=C2C(C3=CC=C(C=C13)O)=O)O. InChi Code: InChI=1S/C14H8O4/c15-7-1-3-9-11(5-7)14(18)10-4-2-8(16)6-12(10)13(9)17/h1-6,15-16H. InChi Key: APAJFZPFBHMFQR-UHFFFAOYSA-N. Origin: Synthetic.
Keywords: | 2,6-DHAQ, 2,6-Dihydroxyanthraquinone, NSC 33531, 2,6-dihydroxy-9,10-anthracenedione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 39246 |
Properties
Application: | Bioactive anthraquinone |
MW: | 240.2 D |
Formula: | C14H8O4 |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 84-60-6| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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