Annaosanchun

Annaosanchun is a synthetic sterol and neuroprotectant agent. It increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons when used at concentrations of 0.1, 0.3, and 1 µM. Annaosanchun (10 µM) prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons. It reduces neurological and neuromuscular deficits and infarct volume in a rat model of ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at doses of 0.5, 2, or 10 mg/kg.Formal Name: androstane-3beta,5alpha,6beta-triol. CAS Number: 4725-51-3. Molecular Formula: C19H32O3. Formula Weight: 308.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, Chloroform: Soluble. SMILES: C[C@@]12[C@]3([H])[C@](C[C@H]([C@]1(C[C@H](CC2)O)O)O)([H])[C@@]4([H])[C@](CC3)(CCC4)C. InChi Code: InChI=1S/C19H32O3/c1-17-7-3-4-14(17)13-10-16(21)19(22)11-12(20)5-9-18(19,2)15(13)6-8-17/h12-16,20-22H,3-11H2,1-2H3/t12-,13-,14-,15-,16+,17-,18+,19-/m0/s1. InChi Key: IFRIPYPBJCUNAG-OTMXHXQLSA-N.