Anacardic Acid monoene

Extracts of the leaves and fruit of Ginkgo plants have long been used in traditional medicine and have multiple potential therapeutic applications, including ameliorating dementia. However, ginkgolic acids, 2-hydroxy-6-alkylbenzoic acids related to anacardic acids, may be deleterious components in these extracts. Ginkgolic acid C15:1 is a 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position. It inhibits SUMOylation in vitro (IC50 = 3 µM) and in cells without affecting protein ubiquitination. Ginkgolic acid C15:1 directly binds the SUMO-activating enzyme E1, blocking the formation of the E1-SUMO intermediate. Ginkgolic acid C15:1 also suppresses the development of pancreatic cancer xenografts in mice.Formal Name: 2-hydroxy-6-(8Z)-8-pentadecenyl-benzoic acid. CAS Number: 22910-60-7. Synonyms: Anacardic Acid 15:1, Ginkgolic Acid I, Ginkogolic Acid C15:1. Molecular Formula: C22H34O3. Formula Weight: 346.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 30 mg/ml, Ethanol: 50 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 243, 311 nm. SMILES: OC1=CC=CC(CCCCCCC/C=C\CCCCCC)=C1C(O)=O. InChi Code: InChI=1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-. InChi Key: YXHVCZZLWZYHSA-FPLPWBNLSA-N.