alpha-Humulene

alpha-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities. It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively). alpha-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml. It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes. In vivo, alpha-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-alpha and IL-1beta production and paw edema in mice and rats. It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.Formal Name: 2,6,6,9-tetramethyl-1E,4E,8E-cycloundecatriene. CAS Number: 6753-98-6. Synonyms: alpha-Caryophyllene, (±)-alpha-Humulene. Molecular Formula: C15H24. Formula Weight: 204.4. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: Methanol: 10 mg/ml. SMILES: C/C1=C\CC/C(C)=C/CC(C)(C)/C=C/C1. InChi Code: InChI=1S/C15H24/c1-13-7-5-8-14(2)10-12-15(3,4)11-6-9-13/h6-7,10-11H,5,8-9,12H2,1-4H3/b11-6+,13-7+,14-10+. InChi Key: FAMPSKZZVDUYOS-HRGUGZIWSA-N.