Alisol A

Alisol A is a terpenoid that has been found in A. orientale and has diverse biological activities. It inhibits the secretion of hepatitis B virus (HBV) surface antigen in HBV-infected 2.2.15 cells (IC50 = 39 µM). Alisol A (20 and 40 µM) induces cell cycle arrest at the G0/G1 phase and autophagy in MDA-MB-231 human breast cancer cells. It reduces hepatic steatosis and increases in plasma triglyceride, total cholesterol, LDL-C, and HDL-C levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 100 mg/kg per day. Alisol A decreases blood glucose and insulin levels in intraperitoneal glucose and insulin tolerance tests, respectively, in the same model.Formal Name: (8alpha,9beta,14beta)-11beta,23S,24R,25-tetrahydroxy-dammar-13(17)-en-3-one. CAS Number: 19885-10-0. Molecular Formula: C30H50O5. Formula Weight: 490.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: C[C@@]12[C@]([C@H](CC3=C([C@H](C)C[C@H](O)[C@@H](O)C(C)(O)C)CC[C@@]32C)O)([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC1)C. InChi Code: InChI=1S/C30H50O5/c1-17(15-21(32)25(34)27(4,5)35)18-9-13-29(7)19(18)16-20(31)24-28(6)12-11-23(33)26(2,3)22(28)10-14-30(24,29)8/h17,20-22,24-25,31-32,34-35H,9-16H2,1-8H3/t17-,20+,21+,22+,24+,25-,28+,29+,30+/m1/s1. InChi Key: HNOSJVWYGXOFRP-UNPOXIGHSA-N. Origin: Plant/Alisma orientalis.