Alclometasone Dipropionate

Alclometasone dipropionate (ACM) is a corticosteroid. It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 µl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes. Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.Formal Name: 7alpha-chloro-11beta-hydroxy-16alpha-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione. CAS Number: 66734-13-2. Synonyms: ACM, Alclometasone 17,21-Dipropionate, SCH 22219. Molecular Formula: C28H37ClO7. Formula Weight: 521.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.2 mg/ml. lambdamax: 244 nm. SMILES: O=C1C=C[C@@]2(C)C(C[C@@H](Cl)[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(COC(CC)=O)=O)OC(CC)=O)=C1. InChi Code: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1. InChi Key: DJHCCTTVDRAMEH-DUUJBDRPSA-N.