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Alclometasone dipropionate (ACM) is a corticosteroid. It reduces cutaneous anaphylaxis reactions... more
Product information "Alclometasone Dipropionate"
Alclometasone dipropionate (ACM) is a corticosteroid. It reduces cutaneous anaphylaxis reactions induced by tuberculin or albumin in mice when administered topically (20 µl of a 0.1% solution). ACM also inhibits androgen-dependent cytochrome P450 activity and the O-depropylation activity of 7-alkoxy-coumarin O-dealkylase in a dose-dependent manner in male rats but has no effect on hepatic drug metabolism in female rats or mice of both sexes. Formulations containing ACM have been used to treat radiation and allergic contact dermatitis.Formal Name: 7alpha-chloro-11beta-hydroxy-16alpha-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione. CAS Number: 66734-13-2. Synonyms: ACM, Alclometasone 17,21-Dipropionate, SCH 22219. Molecular Formula: C28H37ClO7. Formula Weight: 521.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.2 mg/ml. lambdamax: 244 nm. SMILES: O=C1C=C[C@@]2(C)C(C[C@@H](Cl)[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@@]4(C(COC(CC)=O)=O)OC(CC)=O)=C1. InChi Code: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1. InChi Key: DJHCCTTVDRAMEH-DUUJBDRPSA-N.
Keywords: | ACM, Alclometasone 17,21-Dipropionate, SCH 22219, 7alpha-chloro-11beta-hydroxy-16alpha-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 23901 |
Properties
Application: | Glucocorticoid receptor agonist |
MW: | 521 D |
Formula: | C28H37ClO7 |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 66734-13-2| Matching products |
KEGG ID : | K05771 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
|
H Phrases: | H301, H312, H315, H319, H332, H360, H373 |
P Phrases: | P201, P202, P260, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P312, P314, P321, P330, P332+313, P337+313, P361+364, P362+364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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