ADT-OH

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. It can be readily esterified with other moieties. For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 (Cay-13045). ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 (Cay-17100), which selectively increases mitochondrial H2S levels. ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.Formal Name: 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione. CAS Number: 18274-81-2. Synonyms: ACS1. Molecular Formula: C9H6OS3. Formula Weight: 226.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 234, 354, 430 nm. SMILES: OC1=CC=C(C2=CC(SS2)=S)C=C1. InChi Code: InChI=1S/C9H6OS3/c10-7-3-1-6(2-4-7)8-5-9(11)13-12-8/h1-5,10H. InChi Key: IWBBKLMHAILHAR-UHFFFAOYSA-N.