Acetyl-CoA Synthase Inhibitor

Acetyl-CoA synthase inhibitor is an inhibitor of acetyl-CoA synthetase 2 (ACCS2, IC50 = 1.214 µM). It reduces oleic acid-induced increases in the number of histone H2AX-positive cells, a marker of DNA damage, in cultured human immortalized hepatocytes when used at a concentration of 50 µM.Formal Name: N-(2,3-di-2-thienyl-6-quinoxalinyl)-N'-(2-methoxyethyl)-urea. CAS Number: 508186-14-9. Synonyms: ACCS2 Inhibitor, MDK6149, VY-3-249. Molecular Formula: C20H18N4O2S2. Formula Weight: 410.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 221, 273, 400 nm. SMILES: O=C(NCCOC)NC1=CC2=C(N=C(C3=CC=CS3)C(C4=CC=CS4)=N2)C=C1. InChi Code: InChI=1S/C20H18N4O2S2/c1-26-9-8-21-20(25)22-13-6-7-14-15(12-13)24-19(17-5-3-11-28-17)18(23-14)16-4-2-10-27-16/h2-7,10-12H,8-9H2,1H3,(H2,21,22,25). InChi Key: CTPVNWVUAGMHEJ-UHFFFAOYSA-N.