Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

Lipids are small,  organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids.... read more »
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Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

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Oleic Acid
Oleic Acid

Item number: Cay90260-500

Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic...
Keywords: cis-9-Octadecenoic acid, 9Z-octadecenoic acid
Application: Bioactive lipid assays
CAS 112-80-1
MW: 282.5 D
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12(S)-HETE-d8
12(S)-HETE-d8

Item number: Cay334570-25

12(S)-HETE-d8 is intended for use as an internal standard for the quantification of 12-HETE by GC- or LC-MS. (±)12-HETE is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 12(S)- and 12(R)-HETE are formed by 12(S)- and 12(R)-lipoxygenase-mediated oxidation of arachidonic...
Keywords: 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid
Application: Standard
CAS 84807-90-9
MW: 328.5 D
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12(S)-HETE
12(S)-HETE

Item number: Cay34570-25

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 µM.Formal Name: 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid. CAS Number: 54397-83-0. Synonyms: 12(S)-Hydroxyeicosatetraenoic Acid....
Keywords: 12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 54397-83-0
MW: 320.5 D
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Myriocin
Myriocin

Item number: Cay63150-5

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the...
Keywords: ISP-1, Thermozymocidin, 2S-amino-3R,4R-dihydroxy-2-(hydroxymethyl)-14-oxo-6E-eicosenoic acid
Application: Serine palmitoyltransferase inhibitor
CAS 35891-70-4
MW: 401.5 D
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Maresin 1
Maresin 1

Item number: Cay10878-10

Maresin 1 is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from docosahexaenoic acid (DHA, Cay-90310, Cay-17950) in human peripheral blood mononuclear cells (PBMCs). Maresin 1 (100 nM) reduces TNF-alpha-induced increases in reactive oxygen species (ROS) in...
Keywords: 7(R)-MaR1, 7(R)-Maresin 1, 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid
Application: Inflammation studies
CAS 1268720-28-0
MW: 360.5 D
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Dihomo-gamma-Linolenic Acid
Dihomo-gamma-Linolenic Acid

Item number: Cay90230-10

Dihomo-gamma-Linolenic Acid (DGLA, 20:3), an elongation product of gamma-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, including PGE1. In mice, DGLA supplementation...
Keywords: cis-8,11,14-Eicosatrienoic Acid, DGLA, gamma-Homolinolenic Acid, 8Z,11Z,14Z-eicosatrienoic acid
Application: LTB4 receptor antagonist
CAS 1783-84-2
MW: 306.5 D
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1-Oleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)
1-Oleoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

Item number: Cay62215-5

1-Oleoyl-2-hydroxy-sn-glycero-3-PA is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by phosphorylation of DAG by diglycerol kinase....
Keywords: Oleoyl-sn-3-glycerophosphate, 9Z-octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, monosodium salt
Application: Bioactive lipid assays
CAS 325465-93-8
MW: 458.5 D
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(±)19(20)-EpDPA
(±)19(20)-EpDPA

Item number: Cay10175-500

(±)-19(20)-EpDPA is an epoxide metabolite of docosahexaenoic acid (DHA, Cay-90310, Cay-17950). It is formed from DHA by various cytochrome P450 (CYP) isoforms. In vivo, (±)-19(20)-EpDPA (100 ng/animal, i.p.) suppresses hepatic crown-like structure (hCLS) formation and liver fibrosis in wild-type, but not...
Keywords: (±)19,20 EDP, (±)19,20-EpDPE, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA,...
Application: CYP450 metabolism studies
MW: 344.5 D
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alpha-Linolenic Acid
alpha-Linolenic Acid

Item number: Cay90210-50

alpha-Linolenic acid (ALA) is an essential omega-3 polyunsaturated fatty acid found in plants. It is converted to the longer-chain fatty acids eicosapentaenoic (Cay-90110, Cay-90110.1, Cay-21908), docosapentaenoic (Cay-90165, Cay-21907), and docosahexaenoic acid (Cay-90310). It is also catabolized via fatty acid...
Keywords: ALA, C18:3 (9Z,12Z,15Z), C18:3 n-3, 9Z,12Z,15Z-octadecatrienoic acid
Application: Bioactive lipid studies
CAS 463-40-1
MW: 278.4 D
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8-iso-15-keto Prostaglandin F2alpha
8-iso-15-keto Prostaglandin F2alpha

Item number: Cay16390-100

8-iso-15-keto Prostaglandin F2alpha (8-iso-15-keto PGF2alpha) is a metabolite of the isoprostane 8-iso PGF2alpha in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2alpha) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2alpha is...
Keywords: 8-epi-15-keto PGF2alpha, 8-iso-15-keto PGF2alpha, 9alpha,11alpha-dihydroxy-15-oxo-(8beta)-prosta-5Z,13E-dien-1-oic acid
Application: 8-iso PGF2alpha metabolite, vasoconstrictor
CAS 191919-01-4
MW: 352.5 D
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Fingolimod (hydrochloride)
Fingolimod (hydrochloride)

Item number: Cay10006292-50

Fingolimod is an immune modulator, a prodrug form of the sphingosine-1-phosphate (S1P) receptor agonist FTY720 phosphate (Cay-10008639), and a derivative of myriocin (Cay-63150). It selectively inhibits calcium-dependent cytosolic phospholipase A2 (cPLA2) over calcium-independent PLA2 (iPLA2) and secretory PLA2...
Keywords: FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
Application: Immune Modulator
CAS 162359-56-0
MW: 343.9 D
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Palmitic Acid
Palmitic Acid

Item number: Cay10006627-10

Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively. Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid...
Keywords: C16:0, hexadecanoic acid
Application: Bioactive lipid assays
CAS 57-10-3
MW: 256.4 D
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