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A1-28
Item number: Cay39590-10
A1-28 is a disulfide bond-containing ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.Formal Name: bis(2-(dodecyldisulfaneyl)ethyl)...
| Keywords: | AMAP-O16B, bis(2-(dodecyldisulfaneyl)ethyl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 1142.9 D |
From 219.00€
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DU-14
Item number: Cay39665-1
DU-14 is a steroid sulfatase inhibitor (IC50 = 55.8 nM). It inhibits the proliferation of MCF-7 breast cancer cells (IC50 = 38.7 nM). In vivo, DU-14 (30 mg/kg), in combination with the steroid precursor dehydroepiandrosterone sulfate (DHEAS, Cay-15873), potentiates DHEAS reversal of scopolamine-induced amnesia in...
| Keywords: | (p-O-Sulfamoyl)-N-Tetradecanoyltyramine, N-[2-[4-[(aminosulfonyl)oxy]phenyl]ethyl]-tetradecanamide |
| Application: | Steroid sulfatase inhibitor |
| CAS | 186303-55-9 |
| MW: | 426.6 D |
From 35.00€
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BODIPY 480/508-Cholesteryl Linoleate
Item number: Cay39684-1
BODIPY 480/508-cholesteryl linoleate is a cell-permeable and fluorescently tagged derivative of cholesteryl linoleate (Cay-22597). BODIPY 480/508-cholesteryl linoleate displays excitation/emission maxima of 480/508 nm, respectively, and has been used to monitor cholesterol trafficking in isolated human...
| Keywords: | BODIPY 480/508-Cholesterol Linoleate,... |
| Application: | Fluorescently tagged cholesterol ester, cholesterol trafficking monitoring |
| CAS | 2260795-60-4 |
| MW: | 839 D |
From 272.00€
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BODIPY 480/508-Cholesteryl Oleate
Item number: Cay39685-1
BODIPY 480/508-cholesteryl oleate is a cell-permeable and fluorescently tagged derivative of cholesteryl oleate (Cay-26472). BODIPY 480/508-cholesteryl oleate displays excitation/emission maxima of 480/508 nm, respectively, and has been used to monitor cholesterol trafficking in HeLa cells.Formal Name:...
| Keywords: | BODIPY 480/508-Cholesterol Oleate,... |
| Application: | Fluorescently tagged cholesterol ester, cholesterol trafficking monitoring |
| MW: | 841.1 D |
From 136.00€
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IAJD93
Item number: Cay39688-10
IAJD93 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.25). It co-assembles with mRNA to form dendrimersome nanoparticles (DNPs) in acetate buffer. IAJD93 co-assembled with luciferase mRNA delivers the mRNA to the spleen, liver, lungs, and lymph nodes in mice.Formal Name:...
| Keywords: | Ionizable Amphiphilic Janus Dendrimer 93, 3-((2-ethylhexyl)oxy)-2,2-bis(((2-ethylhexyl)oxy)methyl)propyl... |
| Application: | Ionizable amphiphilic Janus dendrimer mRNA delivery system, dendrimersome nanoparticle formation |
| MW: | 671 D |
From 136.00€
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IAJD249
Item number: Cay39689-10
IAJD249 is an ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA (pKa = 6.35). It co-assembles with mRNA to form dendrimersome nanoparticles (DNPs) in acetate buffer. IAJD249 co-assembled with luciferase mRNA delivers the mRNA to the spleen, liver, lungs, and lymph nodes in mice.Formal Name:...
| Keywords: | Ionizable Amphiphilic Janus Dendrimer 249, 3-(octyloxy)-2,2-bis((octyloxy)methyl)propyl... |
| Application: | Ionizable amphiphilic Janus dendrimer mRNA delivery system, dendrimersome nanoparticle formation |
| MW: | 671 D |
From 171.00€
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Tirzepatide (sodium salt)
Item number: Cay39748-1
Tirzepatide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and gastric inhibitory polypeptide (GIP) receptor. It induces cAMP production in HEK293 cells expressing human GLP-1R or human GIP receptor (EC50s = 6.54 and 1.01 nM, respectively). Tirzepatide (100 nM) induces receptor internalization in HEK293...
| Keywords: | LY3298176,... |
| Application: | Dual GLP-1R / GIPR agonist |
| MW: | 4813.5 D |
From 39.00€
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Lipid 331
Item number: Cay39771-1
Lipid 331 is a biodegradable cyclic ionizable cationic lipid (pKa = 7.53) that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid 331 and encapsulating 5-methoxyuridine-modified mRNA encoding ovalbumin induce IFN regulatory factor (IRF)...
| Keywords: | di((9Z,12Z)-octadeca-9,12-dien-1-yl)... |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 978.5 D |
From 149.00€
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Ganoderenic Acid D
Item number: Cay39774-1
Ganoderenic acid D is a triterpenoid originally isolated from G. lucidum and has diverse biological activities. It inhibits angiotensin-converting enzyme (ACE, IC50 = 734 µM). Ganoderenic acid D is cytotoxic to HepG2 liver, HeLa cervical, and Caco-2 colon cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml,...
| Keywords: | (7beta,20E)-7-hydroxy-3,11,15,23-tetraoxo-lanosta-8,20(22)-dien-26-oic acid |
| Application: | Bioactive triterpenoid |
| CAS | 100665-43-8 |
| MW: | 512.6 D |
From 95.00€
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Ganodermanondiol
Item number: Cay39776-1
Ganodermanondiol is a triterpenoid that has been found in G. lucidum and has diverse biological activities. It inhibits the proliferation of Meth A sarcoma and LLC1 lung carcinoma cells (IC50s = 3.4 and 12.5 µg/ml, respectively). Ganodermanondiol (20 µM) reduces the viability of RAW 264.7 macrophages. It inhibits...
| Keywords: | 24S,25-dihydroxy-lanosta-7,9(11)-dien-3-one |
| Application: | Bioactive triterpenoid |
| CAS | 107900-76-5 |
| MW: | 456.7 D |
From 75.00€
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Benzydamine (hydrochloride)
Item number: Cay39808-10
Benzydamine is a non-steroidal anti-inflammatory drug (NSAID). It decreases the viability of THP-1 monocytes, Saos-2 osteosarcoma, and HGF-1 gingival cancer cells (IC50s = 59.08, 30.79, and 52.06 µg/ml, respectively). Benzydamine (10 µg/ml) reduces LPS-induced increases in the levels of IL-6 and TNF-alpha secreted...
| Keywords: | N,N-dimethyl-3-[[1-(phenylmethyl)-1H-indazol-3-yl]oxy]-1-propanamine, monohydrochloride |
| Application: | NSAID, COX inhibitor |
| CAS | 132-69-4 |
| MW: | 345.9 D |
From 40.00€
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5,7,3',4',5'-Pentamethoxyflavone
Item number: Cay39820-10
5,7,3',4',5'-Pentamethoxyflavone is a flavonoid that has been found in M. paniculata and has diverse biological activities. It inhibits pancreatic lipase in a cell-free assay and reduces lipid accumulation in 3T3-L1 adipocytes in a concentration-dependent manner. 5,7,3',4',5'-Pentamethoxyflavone inhibits...
| Keywords: | 3',4',5',5,7-Pentamethoxyflavone, 5,7,3',4',5'-PMF, 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one |
| Application: | Bioactive flavonoid |
| CAS | 53350-26-8 |
| MW: | 372.4 D |
From 62.00€
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