Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

Lipids are small,  organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids.... read more »
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Lipids

Lipids are small, organic molecules, that are usually hydrophobic or amphiphillic. For example, this group includes fats, fatty acids, waxes, triglycerides, sterols and phospholipids. Lipids are the main structural component of biological membranes of all cells. As such, bacterial lipid structures and glycolipids can serve as pathogen-associated molecular patterns (PAMPs) and are recognized by the human immune system. Various lipids and lipid complexes of bacterial origin are therefore used as immunostimulants.

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Prostaglandin E3
Prostaglandin E3

Item number: Cay14990-50

Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.Formal Name:...
Keywords: PGE3, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid
Application: Bioactive lipid assays
CAS 802-31-3
MW: 350.5 D
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16alpha-hydroxy Dehydroepiandrosterone
16alpha-hydroxy Dehydroepiandrosterone

Item number: Cay34116-1

16alpha-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone (Cay-15728). 16alpha-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as...
Keywords: 16a-hydroxy DHEA, 3,16-dihydroxy-(3beta,16a)-androst-5-en-17-one
Application: Dehydroepiandrosterone metabolite
CAS 1232-73-1
MW: 304.4 D
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1,2-Didocosahexaenoyl-sn-glycero-3-PC
1,2-Didocosahexaenoyl-sn-glycero-3-PC

Item number: Cay10733-1

1,2-Didocosahexaenoyl-sn-glycero-3-PC is a phospholipid that contains docosahexaenoic acid (Cay-90310, Cay-17950) at the sn-1 and sn-2 positions. It has been used in the formation of polyunsaturated endoplasmic reticulum-targeting liposomes (PERLs) that reduce cellular cholesterol levels in human peripheral blood...
Keywords: 1,2-Didocosahexaenoin-sn-glycero-3-Phosphatidylcholine, 1,2-Didocosahexaenoyl PC,...
Application: Phospholipid
CAS 99296-81-8
MW: 878.2 D
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Thielavin A
Thielavin A

Item number: Cay21767-2.5

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B (Cay-18770). Thielavin A inhibits COX, blocking both the conversion of arachidonic acid (Cay-90010) to prostaglandin H2 (PGH2, Cay-17020) and the conversion of PGH2 to PGE2 (Cay-14010, IC50s = 10 and 40 µM,...
Keywords: 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-benzoic acid,...
Application: Fungal metabolite, COX inhibitor
CAS 71950-66-8
MW: 538.5 D
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10(S)-HOME
10(S)-HOME

Item number: Cay33246-1

10(S)-HOME is an oxylipin. It is an intermediate in the conversion of oleic acid (Cay-90260, Cay-24659) to the antibacterial hydroxy fatty acid 7,10-dihydroxy-8(E)-octadecenoic acid (Cay-33447) in P. aeruginosa.Formal Name: 10S-hydroxy-8E-octadecenoic acid. CAS Number: 263023-34-3. Synonyms: HOD. Molecular Formula:...
Keywords: HOD, 10S-hydroxy-8E-octadecenoic acid
Application: Oxylipin
CAS 263023-34-3
MW: 298.5 D
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ATX-100
ATX-100

Item number: Cay36935-1

ATX-100 is an ionizable cationic lipid (pKa = 6.38). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. Intravenous administration of LNPs containing ATX-100 and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice.Formal Name:...
Keywords: 4,4'-[[[[3-(dimethylamino)propyl]thio]carbonyl]imino]bis-butanoic acid, 1,1'-bis(1-heptyloctyl) ester
Application: Cationic ionizable lipid
CAS 2230647-37-5
MW: 755.2 D
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Lipid C24
Lipid C24

Item number: Cay37122-1

Lipid C24 is a cationic ionizable lipid. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).Formal Name: bis(2-octyldodecyl) 3,3'-((4-(4-methylpiperazin-1-yl)butyl)azanediyl)dipropionate. CAS Number: 2767561-52-2. Molecular Formula: C55H109N3O4. Formula Weight: 876.5....
Keywords: bis(2-octyldodecyl) 3,3'-((4-(4-methylpiperazin-1-yl)butyl)azanediyl)dipropionate
Application: Cationic ionizable lipid, LNP formation
CAS 2767561-52-2
MW: 876.5 D
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FTT5
FTT5

Item number: Cay37413-1

FTT5 is a lipid-like compound that has been used in the formation of lipid-like nanoparticles (LLNs) and is a derivative of the ionizable cationic amino lipid TT3 (Cay-37909). LLNs containing FTT5 and encapsulating an mRNA reporter increase luminescence in Hep3B cells and selectively accumulate in mouse liver. LLNs...
Keywords: Functionalized N1,N3,N5-tris(2-aminoethyl)benzene-1,3,5-Tricarboxamide 5,...
Application: Lipid-like compound, LLN formation
CAS 2803606-43-9
MW: 1989.1 D
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OF-02
OF-02

Item number: Cay37652-1

OF-02 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing OF-02 localize to the liver after intravenous administration in mice. Intravenous administration of LNPs containing OF-02 and...
Keywords: 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-2,5-piperazinedione
Application: Ionizable cationic amino lipid, LNP formation
CAS 1883431-67-1
MW: 1314.1 D
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TT3
TT3

Item number: Cay37909-1

TT3 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid-like nanoparticles (LLNs). Administration of LLNs containing TT3 and encapsulating mRNA encoding human coagulation Factor IX induces human coagulation Factor IX expression in the plasma of...
Keywords: N1,N3,N5-tris[3-(didodecylamino)propyl]-1,3,5-benzenetricarboxamide
Application: Ionizable cationic amino lipid, LLN formation
CAS 1821214-50-9
MW: 1388.4 D
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306-N16B
306-N16B

Item number: Cay37927-1

306-N16B is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-N16B and encapsulating an mRNA reporter accumulate specifically in the mouse lung primarily in lung endothelial cells. LNPs containing both 306-N16B and...
Keywords: 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfaneyl)ethyl)propanamide)
Application: Ionizable cationic lipid, LNP formation
CAS 2803699-70-7
MW: 1471.6 D
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Lipid OA2 (hydrochloride)
Lipid OA2 (hydrochloride)

Item number: Cay37987-10

Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA. LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated...
Keywords: KE-oleyl, di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, dihydrochloride
Application: Ionizable cationic lipid, LNP formation
MW: 849.1 D
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