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Prostaglandin E3
Item number: Cay14990-50
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. In human ocular tissue, it comprises 2.4% of the COX products formed. When applied to the eyes of a rabbit, a 1 µg dose of PGE3 decreases intraocular pressure from 21 mmHg to about 17 mmHg.Formal Name:...
| Keywords: | PGE3, 9-oxo-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid |
| Application: | Bioactive lipid assays |
| CAS | 802-31-3 |
| MW: | 350.5 D |
From 193.00€
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16alpha-hydroxy Dehydroepiandrosterone
Item number: Cay34116-1
16alpha-hydroxy Dehydroepiandrosterone is a metabolite of the endogenous steroid hormone dehydroepiandrosterone (Cay-15728). 16alpha-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as...
| Keywords: | 16a-hydroxy DHEA, 3,16-dihydroxy-(3beta,16a)-androst-5-en-17-one |
| Application: | Dehydroepiandrosterone metabolite |
| CAS | 1232-73-1 |
| MW: | 304.4 D |
From 85.00€
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1,2-Didocosahexaenoyl-sn-glycero-3-PC
Item number: Cay10733-1
1,2-Didocosahexaenoyl-sn-glycero-3-PC is a phospholipid that contains docosahexaenoic acid (Cay-90310, Cay-17950) at the sn-1 and sn-2 positions. It has been used in the formation of polyunsaturated endoplasmic reticulum-targeting liposomes (PERLs) that reduce cellular cholesterol levels in human peripheral blood...
| Keywords: | 1,2-Didocosahexaenoin-sn-glycero-3-Phosphatidylcholine, 1,2-Didocosahexaenoyl PC,... |
| Application: | Phospholipid |
| CAS | 99296-81-8 |
| MW: | 878.2 D |
From 54.00€
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Thielavin A
Item number: Cay21767-2.5
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B (Cay-18770). Thielavin A inhibits COX, blocking both the conversion of arachidonic acid (Cay-90010) to prostaglandin H2 (PGH2, Cay-17020) and the conversion of PGH2 to PGE2 (Cay-14010, IC50s = 10 and 40 µM,...
| Keywords: | 4-[(2,4-dihydroxy-3,6-dimethylbenzoyl)oxy]-2-hydroxy-3,5,6-trimethyl-benzoic acid,... |
| Application: | Fungal metabolite, COX inhibitor |
| CAS | 71950-66-8 |
| MW: | 538.5 D |
From 390.00€
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10(S)-HOME
Item number: Cay33246-1
10(S)-HOME is an oxylipin. It is an intermediate in the conversion of oleic acid (Cay-90260, Cay-24659) to the antibacterial hydroxy fatty acid 7,10-dihydroxy-8(E)-octadecenoic acid (Cay-33447) in P. aeruginosa.Formal Name: 10S-hydroxy-8E-octadecenoic acid. CAS Number: 263023-34-3. Synonyms: HOD. Molecular Formula:...
| Keywords: | HOD, 10S-hydroxy-8E-octadecenoic acid |
| Application: | Oxylipin |
| CAS | 263023-34-3 |
| MW: | 298.5 D |
From 67.00€
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ATX-100
Item number: Cay36935-1
ATX-100 is an ionizable cationic lipid (pKa = 6.38). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. Intravenous administration of LNPs containing ATX-100 and encapsulating Factor VII siRNA decrease Factor VII blood levels in mice.Formal Name:...
| Keywords: | 4,4'-[[[[3-(dimethylamino)propyl]thio]carbonyl]imino]bis-butanoic acid, 1,1'-bis(1-heptyloctyl) ester |
| Application: | Cationic ionizable lipid |
| CAS | 2230647-37-5 |
| MW: | 755.2 D |
From 62.00€
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Lipid C24
Item number: Cay37122-1
Lipid C24 is a cationic ionizable lipid. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs).Formal Name: bis(2-octyldodecyl) 3,3'-((4-(4-methylpiperazin-1-yl)butyl)azanediyl)dipropionate. CAS Number: 2767561-52-2. Molecular Formula: C55H109N3O4. Formula Weight: 876.5....
| Keywords: | bis(2-octyldodecyl) 3,3'-((4-(4-methylpiperazin-1-yl)butyl)azanediyl)dipropionate |
| Application: | Cationic ionizable lipid, LNP formation |
| CAS | 2767561-52-2 |
| MW: | 876.5 D |
From 54.00€
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FTT5
Item number: Cay37413-1
FTT5 is a lipid-like compound that has been used in the formation of lipid-like nanoparticles (LLNs) and is a derivative of the ionizable cationic amino lipid TT3 (Cay-37909). LLNs containing FTT5 and encapsulating an mRNA reporter increase luminescence in Hep3B cells and selectively accumulate in mouse liver. LLNs...
| Keywords: | Functionalized N1,N3,N5-tris(2-aminoethyl)benzene-1,3,5-Tricarboxamide 5,... |
| Application: | Lipid-like compound, LLN formation |
| CAS | 2803606-43-9 |
| MW: | 1989.1 D |
From 90.00€
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OF-02
Item number: Cay37652-1
OF-02 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing OF-02 localize to the liver after intravenous administration in mice. Intravenous administration of LNPs containing OF-02 and...
| Keywords: | 3,6-bis[4-[bis[(9Z,12Z)-2-hydroxy-9,12-octadecadien-1-yl]amino]butyl]-2,5-piperazinedione |
| Application: | Ionizable cationic amino lipid, LNP formation |
| CAS | 1883431-67-1 |
| MW: | 1314.1 D |
From 103.00€
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TT3
Item number: Cay37909-1
TT3 is an ionizable cationic amino lipid that has been used in combination with other lipids in the formation of lipid-like nanoparticles (LLNs). Administration of LLNs containing TT3 and encapsulating mRNA encoding human coagulation Factor IX induces human coagulation Factor IX expression in the plasma of...
| Keywords: | N1,N3,N5-tris[3-(didodecylamino)propyl]-1,3,5-benzenetricarboxamide |
| Application: | Ionizable cationic amino lipid, LLN formation |
| CAS | 1821214-50-9 |
| MW: | 1388.4 D |
From 62.00€
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306-N16B
Item number: Cay37927-1
306-N16B is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-N16B and encapsulating an mRNA reporter accumulate specifically in the mouse lung primarily in lung endothelial cells. LNPs containing both 306-N16B and...
| Keywords: | 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfaneyl)ethyl)propanamide) |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2803699-70-7 |
| MW: | 1471.6 D |
From 48.00€
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Lipid OA2 (hydrochloride)
Item number: Cay37987-10
Lipid OA2 is an ionizable cationic lipid that has been used in the generation of single-component lipid nanoparticles (LNPs) for the delivery of siRNA. LNPs containing lipid OA2 and siRNA targeting the gene encoding suppressor of cytokine signaling 1 (Socs1) decrease Socs1 expression by approximately 50% in isolated...
| Keywords: | KE-oleyl, di((Z)-octadec-9-en-1-yl) L-lysyl-L-glutamate, dihydrochloride |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 849.1 D |
From 103.00€
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