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12(S)-HHTrE
Item number: Cay34590-25
12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets. It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. 12(S)-HHTrE is a natural lipid agonist of the leukotriene B2 receptor BLT2 in...
| Keywords: | 12(S)-HHT, 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 54397-84-1 |
| MW: | 280.4 D |
From 166.00€
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Arachidonoyl Glycine
Item number: Cay90051-5
Arachidonoyl glycine (N-arachidonyl glycine, NAGly) has been isolated from cell cultures treated with arachidonoyl ethanolamide (AEA, anandamide), from extracts of mammalian brain, and has also been synthesized as an analog of AEA for structure/activity testing. NAGly may be produced endogenously via oxidation of...
| Keywords: | N-Arachidonyl Glycine, NAGly, N-[1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl]-glycine |
| Application: | Analgesic activities |
| CAS | 179113-91-8 |
| MW: | 361.5 D |
From 57.00€
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PPZ-A10
Item number: Cay9004144-5
PPZ-A10 is an ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA in vitro and in vivo. Intraperitoneal administration of LNPs containing PPZ-A10 and encapsulating an mRNA reporter preferentially accumulates in hepatic Kupffer cells and...
| Keywords: | N,N'-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(3-(didecylamino)propanamide) |
| Application: | Ionizable cationic lipid, LNP formation |
| MW: | 903.6 D |
From 130.00€
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Estramustine Phosphate (sodium salt)
Item number: Cay23126-10
Estramustine phosphate is a derivative of estradiol (Cay-20776, Cay-10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 µM for MAP-1 and MAP-2, respectively. Estramustine induces cell...
| Keywords: | Ro 21-8837/001, estra-1,3,5(10)-triene-3,17-diol (17beta)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate),... |
| Application: | Microtubule destabilizer |
| CAS | 52205-73-9 |
| MW: | 564.3 D |
From 40.00€
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Anacardic Acid triene
Item number: Cay26611-1
Anacardic acid triene is a polyunsaturated form of anacardic acid (Cay-13144) that has been found in cashew nut shell liquid. It inhibits soybean lipoxygenase-1 (IC50 = 60 µM in an enzyme assay) and inhibits superoxide production by xanthine oxidase by 82% when used at a concentration of 88 µM. Anacardic acid triene...
| Keywords: | Anacardic Acid 15:3, 2-hydroxy-6-(8Z,11Z)-8,11,14-pentadecatrien-1-yl-benzoic acid |
| Application: | Soybean lipoxygenase-1 inhibitor, antibacterial agent |
| CAS | 103904-73-0 |
| MW: | 342.5 D |
From 116.00€
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cKK-E12
Item number: Cay36700-25
cKK-E12 is an ionizable cationic lipomer that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.Formal Name: 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-2,5-piperazinedione. CAS Number: 1432494-65-9. Molecular Formula: C60H120N4O6. Formula Weight:...
| Keywords: | 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-2,5-piperazinedione |
| Application: | Ionizable cationic lipomer, LNP formation |
| CAS | 1432494-65-9 |
| MW: | 993.6 D |
From 335.00€
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AA3-DLin
Item number: Cay37903-10
AA3-DLin is an ionizable cationic amino lipid (pKa = 5.8) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing AA3-DLin and encapsulating mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike...
| Keywords: | piperazine-1,4-diylbis(ethane-2,1-diyl) (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate) |
| Application: | Ionizable cationic amino lipid |
| MW: | 699.1 D |
From 136.00€
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11-A-M
Item number: Cay39458-5
11-A-M is an ionizable cationic lipid. Lipid nanoparticles (LNPs) containing 11-A-M and encapsulating siRNA for the gene encoding GFP reduce its gene expression selectively in splenic T cells but not hepatocytes in mice that constitutively express GFP.Formal Name: tricyclo[3.3.1.13,7]decane-1-acetic acid,...
| Keywords: | tricyclo[3.3.1.13,7]decane-1-acetic acid,... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2408140-60-1 |
| MW: | 702 D |
From 209.00€
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Sphingosine (d18:1)
Item number: Cay10007907-10
Sphingosine (d18:1) is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase. Phosphorylation of sphingosine by sphingosine kinases 1 and 2 (SPHK 1, SPHK 2) produces...
| Keywords: | (-)-Sphingosine, D-erythro-Sphingosine C-18, 2S-amino-4E-octadecene-1,3R-diol |
| Application: | Bioactive lipid assays |
| CAS | 123-78-4 |
| MW: | 299.5 D |
From 61.00€
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(±)9(10)-DiHOME
Item number: Cay53400-25
(±)9(10)-DiHOME is the diol form of (±)9(10)-EpOME (Cay-52400), a cytochrome P450-derived epoxide of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) also known as leukotoxin. It is formed from 9(10)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. It is toxic to Sf21 cells expressing sEH and to...
| Keywords: | Leukotoxin diol, (±)9,10-dihydroxy-12Z-octadecenoic acid |
| Application: | Cytotoxic agent |
| CAS | 263399-34-4 |
| MW: | 314.5 D |
From 44.00€
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Lipid-based Drug Delivery Tools
1,2-Dimyristoyl-sn-glycero-3-PE
Item number: Cay15090-250
Phosphatidylethanolamines (PEs) are phospholipids found in biological membranes, serving both structural and functional roles. Different types of PEs are commonly used in the generation of micelles, liposomes, and other types of artificial membranes. 1,2-Dimyristoyl-sn-glycero-3-PE (1,2-DMPE) is a phospholipid...
| Keywords: | 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, DMPE, 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine |
| Application: | Phospholipid |
| CAS | 998-07-2 |
| MW: | 635.9 D |
From 69.00€
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5(S),15(S)-DiHETE
Item number: Cay35280-25
5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 µM.Formal Name: 5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic...
| Keywords: | 5S,15S-dihydroxy-6E,8Z,10Z,13E-eicosatetraenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 82200-87-1 |
| MW: | 336.5 D |
From 133.00€
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