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Estramustine Phosphate (sodium salt)
Item number: Cay23126-10
Estramustine phosphate is a derivative of estradiol (Cay-20776, Cay-10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 µM for MAP-1 and MAP-2, respectively. Estramustine induces cell...
| Keywords: | Ro 21-8837/001, estra-1,3,5(10)-triene-3,17-diol (17beta)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate),... |
| Application: | Microtubule destabilizer |
| CAS | 52205-73-9 |
| MW: | 564.3 D |
From 40.00€
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Anacardic Acid triene
Item number: Cay26611-1
Anacardic acid triene is a polyunsaturated form of anacardic acid (Cay-13144) that has been found in cashew nut shell liquid. It inhibits soybean lipoxygenase-1 (IC50 = 60 µM in an enzyme assay) and inhibits superoxide production by xanthine oxidase by 82% when used at a concentration of 88 µM. Anacardic acid triene...
| Keywords: | Anacardic Acid 15:3, 2-hydroxy-6-(8Z,11Z)-8,11,14-pentadecatrien-1-yl-benzoic acid |
| Application: | Soybean lipoxygenase-1 inhibitor, antibacterial agent |
| CAS | 103904-73-0 |
| MW: | 342.5 D |
From 116.00€
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cKK-E12
Item number: Cay36700-25
cKK-E12 is an ionizable cationic lipomer that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.Formal Name: 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-2,5-piperazinedione. CAS Number: 1432494-65-9. Molecular Formula: C60H120N4O6. Formula Weight:...
| Keywords: | 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-2,5-piperazinedione |
| Application: | Ionizable cationic lipomer, LNP formation |
| CAS | 1432494-65-9 |
| MW: | 993.6 D |
From 335.00€
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AA3-DLin
Item number: Cay37903-10
AA3-DLin is an ionizable cationic amino lipid (pKa = 5.8) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing AA3-DLin and encapsulating mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike...
| Keywords: | piperazine-1,4-diylbis(ethane-2,1-diyl) (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate) |
| Application: | Ionizable cationic amino lipid |
| MW: | 699.1 D |
From 136.00€
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11-A-M
Item number: Cay39458-5
11-A-M is an ionizable cationic lipid. Lipid nanoparticles (LNPs) containing 11-A-M and encapsulating siRNA for the gene encoding GFP reduce its gene expression selectively in splenic T cells but not hepatocytes in mice that constitutively express GFP.Formal Name: tricyclo[3.3.1.13,7]decane-1-acetic acid,...
| Keywords: | tricyclo[3.3.1.13,7]decane-1-acetic acid,... |
| Application: | Ionizable cationic lipid, LNP formation |
| CAS | 2408140-60-1 |
| MW: | 702 D |
From 209.00€
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Resolvin D2-d5
Item number: Cay11184-10
Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Cay-10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition to being anti-inflammatory, resolvins...
| Keywords: | 7(S),16(R),17(S)-Resolvin D2-d5, RvD2-d5, 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21',22,22,22-d5 docosahexaenoic acid |
| Application: | Standard, bioactive lipid assays |
| CAS | 1881277-33-3 |
| MW: | 381.5 D |
From 231.00€
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(±)12-HETE
Item number: Cay34550-25
(±)12-HETE is a racemic mixture of the arachidonic acid metabolites 12(R)-HETE (Cay-34560) and 12(S)-HETE (Cay-34570). It is formed via non-enzymatic oxidation of arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607). 12(S)- and 12(R)-HETE are formed by 12S- and 12R-lipoxygenase-mediated oxidation of arachidonic...
| Keywords: | (±)12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid |
| Application: | Bioactive lipid studies |
| CAS | 71030-37-0 |
| MW: | 320.5 D |
From 99.00€
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(±)19(20)-DiHDPA
Item number: Cay10007001-50
Docosahexaenoic acid (DHA, Cay-90310) is an essential fatty acid and the most abundant omega-3 fatty acid in neural tissues, especially in the retina and brain. (±)19(20)-DiHDPA is one of the major metabolites produced when DHA is incubated with NADPH-supplemented rat liver microsomes. DHA is also slowly metabolized...
| Keywords: | (±)19,20-DiHDoPE, (±)19,20-dihydroxy-4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid |
| Application: | Bioactive lipid assays |
| MW: | 362.5 D |
From 116.00€
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9(S)-HODE
Item number: Cay38410-100
9(S)-HODE is a metabolite of the omega-6 polyunsaturated fatty acid linoleic acid (Cay-90150, Cay-90150.1, Cay-21909). It is formed from linoleic acid by lipoxygenases. 9(S)-HODE (68 µM) increases transactivation of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma in reporter assays using...
| Keywords: | 9S-hydroxy-10E,12Z-octadecadienoic acid |
| Application: | Bioactive lipid studies |
| CAS | 73543-67-6 |
| MW: | 296.5 D |
From 161.00€
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Filipin III
Item number: Cay70440-1
Filipin III is a polyene and an active component of the polyene antibiotic filipin complex (Cay-25073). It is active against various fungi, including B. dermatitidis, C. neoformans, H. capsulatum, C. albicans, and T. mentagrophytes (MICs = 1-10 µg/ml). Filipin III induces hemolysis of isolated rabbit erythrocytes...
| Keywords: | 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,21E,23E,25E-pen... |
| Application: | Bioactive lipid assays |
| CAS | 480-49-9 |
| MW: | 654.8 D |
From 150.00€
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beta-Muricholic Acid
Item number: Cay20287-1
beta-Muricholic acid (beta-MCA) is a murine-specific primary bile acid. Dietary administration of beta-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet. Dietary administration of beta-MCA also dissolves 100% of gallstones in a gallstone-susceptible...
| Keywords: | 5beta-Cholanic Acid-3alpha,6beta,7beta-triol, beta-MCA, (5beta)-3alpha,6beta,7beta-trihydroxy-cholan-24-oic acid |
| CAS | 2393-59-1 |
| MW: | 408.6 D |
From 161.00€
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1,2-Didocosahexaenoyl-sn-glycero-3-PC
Item number: Cay10733-1
1,2-Didocosahexaenoyl-sn-glycero-3-PC is a phospholipid that contains docosahexaenoic acid (Cay-90310, Cay-17950) at the sn-1 and sn-2 positions. It has been used in the formation of polyunsaturated endoplasmic reticulum-targeting liposomes (PERLs) that reduce cellular cholesterol levels in human peripheral blood...
| Keywords: | 1,2-Didocosahexaenoin-sn-glycero-3-Phosphatidylcholine, 1,2-Didocosahexaenoyl PC,... |
| Application: | Phospholipid |
| CAS | 99296-81-8 |
| MW: | 878.2 D |
From 54.00€
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