(±)-6-Prenylnaringenin

(±)-6-Prenylnaringenin ((±)-6-PN) is a flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities. It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s = 0.912 and 4.765 µM, respectively). It inhibits proliferation of PC3 and DU145 prostate cancer cells (IC50s = 18.4 and 29.1 µM, respectively). (±)-6-PN (20 and 30 mg/kg) reduces mechanical allodynia in a mouse model of neuropathic pain induced by partial sciatic nerve ligation.Formal Name: 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. CAS Number: 68682-01-9. Synonyms: (±)-6-PN. Molecular Formula: C20H20O5. Formula Weight: 340.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: O=C1C2=C(C(C/C=C(C)\C)=C(C=C2OC(C1)C3=CC=C(C=C3)O)O)O. InChi Code: InChI=1S/C20H20O5/c1-11(2)3-8-14-15(22)9-18-19(20(14)24)16(23)10-17(25-18)12-4-6-13(21)7-5-12/h3-7,9,17,21-22,24H,8,10H2,1-2H3. InChi Key: YHWNASRGLKJRJJ-UHFFFAOYSA-N. Origin: Synthetic.