5,8,11-Eicosatriynoic Acid

5,8,11-ETI is a nonselective inhibitor of lipoxygenases. It inhibits 12-LO in human platelets with an ID50 value of 24 µM. 5,8,11-ETI also inhibits A23187 and L-cysteine induced LTC4 biosynthesis in mouse mastocytoma cells with an ID50 value of 5 µM. At higher concentrations, 5,8,11-ETI also inhibits cyclooxygenases (ID50 = 340 µM).Formal Name: 5,8,11-eicosatriynoic acid. CAS Number: 13488-22-7. Synonyms: 5,8,11-ETI, FA 20:6. Molecular Formula: C20H28O2. Formula Weight: 300.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.15 M Tris-HCl pH 8.5: 1 mg/ml, DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 500 µg/ml, PBS pH 7.2: <50 µg/ml. SMILES: CCCCCCCCCCCCCCCCCCCC(=O)O. InChi Code: InChI=1S/C20H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-8,11,14,17-19H2,1H3,(H,21,22). InChi Key: OWYNLPMPYBYKJP-UHFFFAOYSA-N. Side Chain Carbon Sum: 20:3.