5,7,3',4',5'-Pentamethoxyflavone

5,7,3',4',5'-Pentamethoxyflavone is a flavonoid that has been found in M. paniculata and has diverse biological activities. It inhibits pancreatic lipase in a cell-free assay and reduces lipid accumulation in 3T3-L1 adipocytes in a concentration-dependent manner. 5,7,3',4',5'-Pentamethoxyflavone inhibits transactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) in a reporter assay using HEK293T cells when used at concentrations of 10, 25, or 50 µM. It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and GES-1 cells. 5,7,3',4',5'-Pentamethoxyflavone (25 µM) sensitizes cisplatin-resistant A549 non-small cell lung cancer (NSCLC) cells to the DNA-crosslinking agent cisplatin (Cay-13119). In vivo, 5,7,3',4',5'-pentamethoxyflavone (5 mg/kg) decreases blood glucose levels and renal fibrosis in a rat model of diabetes induced by streptozotocin (STZ, Cay-13104).Formal Name: 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 53350-26-8. Synonyms: 3',4',5',5,7-Pentamethoxyflavone, 5,7,3',4',5'-PMF. Molecular Formula: C20H20O7. Formula Weight: 372.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Methanol: Soluble. SMILES: O=C1C=C(C2=CC(OC)=C(OC)C(OC)=C2)OC3=C1C(OC)=CC(OC)=C3. InChi Code: InChI=1S/C20H20O7/c1-22-12-8-15(23-2)19-13(21)10-14(27-16(19)9-12)11-6-17(24-3)20(26-5)18(7-11)25-4/h6-10H,1-5H3. InChi Key: GIKVSFNAEBQLGB-UHFFFAOYSA-N. Origin: Natural/Source unknown.