4A3-SC8

4A3-SC8 is an ionizable cationic lipid (pKa = 6.66) and a dendrimer that has been used in the preparation of lipid nanoparticles (LNPs). Intratumoral administration of LNPs containing 4A3-SC8 and encapsulating homologous double-strand repair (HDR) elements correct the DNA encoding GFP with a tyrosine-to-histidine mutation at position 66 (GFPY66H) in a HEK293 mouse xenograft model.CAS Number: 1857340-78-3. Molecular Formula: C75H139N3O16S4. Formula Weight: 1467.2. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Soluble, Ethanol: Soluble. SMILES: O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)C)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O. InChi Code: InChI=1S/C75H139N3O16S4/c1-10-14-18-22-26-30-56-95-60-64(5)72(83)91-52-48-87-68(79)36-44-77(45-37-69(80)88-49-53-92-73(84)65(6)61-96-57-31-27-23-19-15-11-2)42-34-40-76(9)41-35-43-78(46-38-70(81)89-50-54-93-74(85)66(7)62-97-58-32-28-24-20-16-12-3)47-39-71(82)90-51-55-94-75(86)67(8)63-98-59-33-29-25-21-17-13-4/h64-67H,10-63H2,1-9H3. InChi Key: HMIDEMNFLBUNTB-UHFFFAOYSA-N.