4-Hydroxyestradiol

4-Hydroxyestradiol is a catechol estrogen and minor metabolite of estrogen. 4-Hydroxyestradiol is formed from estrogen by the cytochrome P450 (CYP) isoform CYP1B1. Production of 4-hydroxyestradiol is increased in microsomes prepared from human mammary adenocarcinoma and fibroadenoma microsomes compared with microsomes prepared from non-cancerous tissues. 4-Hydroxyestradiol (25 mg/animal) induces renal tumor formation in male hamsters.Formal Name: (17beta)-estra-1,3,5(10)-triene-3,4,17-triol. CAS Number: 5976-61-4. Synonyms: 4-Hydroxy-17beta-estradiol. Molecular Formula: C18H24O3. Formula Weight: 288.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C(O)=C4CC3. InChi Code: InChI=1S/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11-,12-,14+,16+,18+/m1/s1. InChi Key: QOZFCKXEVSGWGS-ZHIYBZGJSA-N.