306-O12B
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Larger quantity required? Request bulk
306-O12B is an ionizable cationic lipidoid. It has been used in the generation of lipid... more
Product information "306-O12B"
306-O12B is an ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-O12B and encapsulating an mRNA reporter accumulate specifically in the mouse liver. LNPs containing 306-O12B and encapsulating mRNA encoding the Cas9 nuclease (mCas9) and single-guide RNA targeting Angptl3 (sgAngptl3), the gene encoding angiopoietin-related protein 3, have been used to induce CRISPR-mediated gene knockdown in mice resulting in a reduction of serum Angptl3 protein, LDL, and triglyceride levels.InChI: InChI=1S/C59H115N3O8S8/c1-6-10-14-18-22-26-48-71-75-52-44-67-56(63)32-40-61(41-33-57(64)68-45-53-76-72-49-27-23-19-15-11-7-2)38-30-36-60(5)37-31-39-62(42-34-58(65)69-46-54-77-73-50-28-24-20-16-12-8-3)43-35-59(66)70-47-55-78-74-51-29-25-21-17-13-9-4/h6-55H2,1-5H3 InChIKey: FTXIINBPTFOCHN-UHFFFAOYSA-N SMILES: O=C(OCCSSCCCCCCCC)CCN(CCCN(C)CCCN(CCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O)CCC(OCCSSCCCCCCCC)=O
| Keywords: | tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrapropionate |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 37549 |
Properties
| Application: | Ionizable cationic lipidoid, LNP formation |
| MW: | 1251.1 D |
| Formula: | C59H115N3O8S8 |
| Purity: | >95% |
| Format: | Solution |
Database Information
| CAS : | 2566523-06-4| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H225, H302, H319, H336 |
| P Phrases: | P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+310, P303+361+353, P304+340, P305+351+338, P312, P330, P337+313, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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