246C10

246C10 is an ionizable cationic lipid (pKa = 6.75). It has been used in combination with other lipids in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. Intravenous administration of LNPs containing 246C10 and encapsulating an mRNA reporter selectively accumulate in mouse liver.Formal Name: 1,1',1'',1'''-[1,4-piperazinediylbis(3,1-propanediylnitrilo)]tetrakis-2-dodecanol. CAS Number: 2635329-26-7. Molecular Formula: C58H120N4O4. Formula Weight: 937.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: OC(CCCCCCCCCC)CN(CC(O)CCCCCCCCCC)CCCN(CC1)CCN1CCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC. InChi Code: InChI=1S/C58H120N4O4/c1-5-9-13-17-21-25-29-33-39-55(63)51-61(52-56(64)40-34-30-26-22-18-14-10-6-2)45-37-43-59-47-49-60(50-48-59)44-38-46-62(53-57(65)41-35-31-27-23-19-15-11-7-3)54-58(66)42-36-32-28-24-20-16-12-8-4/h55-58,63-66H,5-54H2,1-4H3. InChi Key: NLIUSFYZNWSAEC-UHFFFAOYSA-N.