21-Deoxycortisol

21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11beta-hydroxylase. Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.Formal Name: 11beta,17-dihydroxy-pregn-4-ene-3,20-dione. CAS Number: 641-77-0. Synonyms: 21-Dehydrohydrocortisone. Molecular Formula: C21H30O4. Formula Weight: 346.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: O=C(C)[C@@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@@]21C)=O. InChi Code: InChI=1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1. InChi Key: LCZBQMKVFQNSJR-UJPCIWJBSA-N.