17beta-Estradiol

17beta-Estradiol is the major pre-menopausal bioactive estrogen and an active metabolite of testosterone. It is produced primarily by the ovary, and to a lesser extent, by the adrenals, testes, and adipose tissue, as well as by the placenta during pregnancy. 17beta-Estradiol binds to estrogen receptors localized to the nucleus, cytoplasm, and plasma membrane and induces gene transcription or non-genomic intracellular signaling in a location-dependent manner. It regulates reproductive development in females and spermatogenesis in males, as well as various non-reproductive processes including lipid and glucose homeostasis, bone mass maintenance, cognition, energy balance, and dilation of blood vessels. 17beta-Estradiol deficiency due to hypogonadism or 17alpha-hydroxylase/17,20-lyase deficiency is associated with fatigue, incontinence, osteoporosis, depression, emotional instability, and hot flashes. Formulations containing 17beta-estradiol have been used in the treatment of menopause symptoms and the prevention of osteoporosis.Formal Name: estra-1,3,5(10)-triene-3,17beta-diol. CAS Number: 50-28-2. Synonyms: E2, Estradiol, beta-Estradiol, 17beta-Oestradiol. Molecular Formula: C18H24O2. Formula Weight: 272.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2)(1:4): 0.2 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 203, 281 nm. SMILES: O[C@H]1CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=C3C=CC(O)=C4. InChi Code: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1. InChi Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N.