15(R)-Prostaglandin I2 (sodium salt)

15(R)-Prostaglandin I2 (15(R)-PGI2) is an isomer of the natural 15(S) prostanoid, PGI2 (Cay-18220). PGI2 is an unstable cyclooxygenase metabolite detected first in vascular endothelial cells. It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM. While the physiological properties of 15(R)-PGI2 are not well known, 15(R) isomers of PGs typically have reduced receptor agonist activity compared to their 15(S) forms.Formal Name: (5Z,9alpha,11alpha,13E,15R)-6,9-epoxy-11,15-dihydroxy-prosta-5,13-dien-1-oic acid, monosodium salt. Synonyms: 15(R)-PGI2. Molecular Formula: C20H31O5 . Na. Formula Weight: 374.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, PBS (pH 9.0): > 11 mg/ml. SMILES: CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(O2)=C/CCCC([O-])=O.[Na+]. InChi Code: InChI=1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22,/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24),/q,+1/p-1/b11-10+,15-8-,/t14-,16-,17-,18-,19+,/m1./s1. InChi Key: LMHIPJMTZHDKEW-MYQOGOCISA-M.