15(R)-15-methyl Prostaglandin F2alpha

15(R)-15-methyl PGF2alpha is a metabolically stable analog of PGF2alpha. 15(R)-15-methyl PGF2alpha is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF2alpha converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.Formal Name: 9alpha,11alpha,15R-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid. CAS Number: 35864-81-4. Synonyms: 15(R)-15-methyl PGF2alpha. Molecular Formula: C21H36O5. Formula Weight: 368.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: 10 mM Na2CO3: >6.5 mg/ml, DMF: >100 mg/ml, DMSO: >100 mg/ml, Ethanol: >100 mg/ml, PBS pH 7.2: >10 mg/ml. SMILES: O[C@@H]1C(C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@](C)(O)CCCCC)[C@H](O)C1. InChi Code: InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16?,17-,18+,19-,21-/m1/s1. InChi Key: DLJKPYFALUEJCK-YLFQPMNTSA-N.