14,15-Leukotriene E4

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils. Mast cells and nasal polyps can synthesize 14,15-LTC4 as well, however metabolism to 14,15-LTE4 in these cells and tissue has not been documented. 14,15-LTE4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency than LTC4, but approximately 100-fold greater potency than histamine.Formal Name: 15S-hydroxy-14R-(S-cysteinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid. CAS Number: 1000852-57-2. Synonyms: Eoxin E4, EXE4, 14,15-LTE4. Molecular Formula: C23H37NO5S. Formula Weight: 439.6. Purity: >97%. Formulation: (Request formulation change), A solution in methanol. Solubility: DMF: > 50mg/ml, DMSO: > 50mg/ml, Ethanol: > 50mg/ml, PBS (pH 7.2): > 100µg/ml. SMILES: CCCCC[C@H](O)[C@H](SC[C@H](N)C(O)=O)/C=C/C=C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C23H37NO5S/c1-2-3-12-15-20(25)21(30-18-19(24)23(28)29)16-13-10-8-6-4-5-7-9-11-14-17-22(26)27/h4,6-10,13,16,19-21,25H,2-3,5,11-12,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/b6-4-,9-7-,10-8+,16-13+/t19?,20-,21+/m0/s1. InChi Key: JLJNENVYAVKECZ-RITCDKMASA-N.