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14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a... more
Product information "14,15-Leukotriene D4"
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.Formal Name: S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-glycine. CAS Number: 75290-64-1. Synonyms: Eoxin D4, EXD4, 14,15-LTD4. Molecular Formula: C25H40N2O6S. Formula Weight: 496.7. Purity: >97%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): >100 µg/ml. lambdamax: 280 nm. SMILES: CCCCC[C@H](O)[C@H](SC[C@H](N)C(NCC(O)=O)=O)/C=C/C=C/C=C\C/C=C\CCCC(O)=O. InChi Code: InChI=1S/C25H40N2O6S/c1-2-3-12-15-21(28)22(34-19-20(26)25(33)27-18-24(31)32)16-13-10-8-6-4-5-7-9-11-14-17-23(29)30/h4,6-10,13,16,20-22,28H,2-3,5,11-12,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b6-4-,9-7-,10-8+,16-13+/t20-,21-,22+/m0/s1. InChi Key: BUTLPEVGZIRJOA-SPCGXPCUSA-N.
Keywords: | 14,15-LTD4, Eoxin D4, EXD4, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-glycine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10011361 |
Properties
MW: | 496.7 D |
Formula: | C25H40N2O6S |
Purity: | >97% |
Format: | Solution |
Database Information
CAS : | 75290-64-1| Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319 |
P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P305+351+338, P337+313, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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