11beta-13,14-dihydro-15-keto Prostaglandin F2alpha-d9

11beta-13,14-dihydro-15-keto Prostaglandin F2alpha-d9 (11beta-13,14-dihydro-15-keto PGF2alpha-d9) is intended for use as an internal standard for the quantification of 11beta-13,14-dihydro-15-keto PGF2alpha (Cay-16540) by GC- or LC-MS. 11beta-13,14-dihydro-15-keto PGF2alpha is a metabolite of prostaglandin D2 (PGD2, Cay-12010) in the 15-hydroxy PGDH pathway. Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11beta-PGF2alpha, as the immediate product, and 11beta-13,14-dihydro-15-keto PGF2alpha in the plasma within 10 minutes. Homogenates of human lung metabolize PGD2 first to 11beta-PGF2alpha and then to 11beta-15-keto-PGF2alpha in the presence of NAD+, but not 11beta-13,14-dihydro-15-keto PGF2alpha. Guinea pig liver and kidney homogenates metabolize PGD2 to 11beta-13,14-dihydro-15-keto PGF2alpha, via 11beta-PGF2alpha, in the presence of NAD+ and NADP+.Formal Name: (Z)-7-((1R,2R,3S,5S)-3,5-dihydroxy-2-(3-oxooctyl-5,5,6,6,7,7,8,8,8-d9)cyclopentyl)hept-5-enoic acid. CAS Number: 2738376-88-8. Synonyms: 11beta-13,14-dihydro-15-keto PGF2alpha-d9, 11-epi 13,14-dihydro-15-keto PGF2alpha-d9. Molecular Formula: C20H25D9O5. Formula Weight: 363.5. Purity: >99% deuterated forms (d1-d9). Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](CCC(CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)[C@@H](O)C1. InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19+/m1/s1/i1D3,2D2,3D2,6D2. InChi Key: VKTIONYPMSCHQI-SCKSEUPPSA-N.