119-23

119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing 119-23 and encapsulating an mRNA reporter show greater intramuscular transfection efficacy compared to LNPs containing the ionizable cationic lipids SM-102 (Cay-33474) or DLin-MC3-DMA (Cay-34364) in mice. 119-23-containing LNPs accumulate in mouse hepatic and splenic immune cells to a greater extent than SM-102-containing LNPs. LNPs containing 119-23 and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.Formal Name: 9Z-octadecenoic acid, 6-[[3-(dimethylamino)propyl][(9Z)-1-oxo-9-octadecen-1-yl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl ester. CAS Number: 2953044-98-7. Molecular Formula: C58H105N3O4. Formula Weight: 908.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: CCCCCCCC/C=C\CCCCCCCC(N(C(CCCCCOC(CCCCCCC/C=C\CCCCCCCC)=O)C(NC1(C[C@@H](C2)C3)CC3CC2C1)=O)CCCN(C)C)=O. InChi Code: InChI=1S/C58H105N3O4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-40-55(62)61(43-38-42-60(3)4)54(57(64)59-58-48-51-45-52(49-58)47-53(46-51)50-58)39-34-33-37-44-65-56(63)41-36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,51-54H,5-18,23-50H2,1-4H3,(H,59,64)/b21-19-,22-20-/t51-,52?,53?,54?,58?. InChi Key: IGAVEEMYGLJEMW-MVCNXQAVSA-N.