11-Dehydrocorticosterone

11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11beta-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone (Cay-18240). Chronic administration 11-dehydrocorticosterone increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice.Formal Name: 21-hydroxy-pregn-4-ene-3,11,20-trione. CAS Number: 72-23-1. Synonyms: 11-DHC, DHCS, Kendall's Compound A, NSC 9702. Molecular Formula: C21H28O4. Formula Weight: 344.4. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 5 mg/mL. SMILES: C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](CC3=O)([C@H](CC4)C(CO)=O)C. InChi Code: InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16+,19+,20-,21-/m0/s1. InChi Key: FUFLCEKSBBHCMO-KJQYFISQSA-N.