11-A-M

11-A-M is an ionizable cationic lipid. Lipid nanoparticles (LNPs) containing 11-A-M and encapsulating siRNA for the gene encoding GFP reduce its gene expression selectively in splenic T cells but not hepatocytes in mice that constitutively express GFP.Formal Name: tricyclo[3.3.1.13,7]decane-1-acetic acid, 2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]-3-[[(9Z,12Z)-1-oxo-9,12-octadecadien-1-yl]oxy]propyl ester. CAS Number: 2408140-60-1. Molecular Formula: C42H71NO7. Formula Weight: 702.0. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 25 mg/ml. SMILES: CCN(CC)CCCOC(OCC(COC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)=O)=O. InChi Code: InChI=1S/C42H71NO7/c1-4-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-39(44)48-32-38(34-50-41(46)47-24-21-23-43(5-2)6-3)33-49-40(45)31-42-28-35-25-36(29-42)27-37(26-35)30-42/h10-11,13-14,35-38H,4-9,12,15-34H2,1-3H3/b11-10-,14-13-/t35-,36+,37-,38?,42?. InChi Key: FNGYOMDNOWZUBX-MAMLCZHLSA-N.