1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (1-arachidoyl LPA) is an agonist of lysophosphatidic acid receptor 1 (LPA1) and a glycerophospholipid containing arachidic acid (Cay-9000339, Cay-21906) at the sn-1 position. It induces calcium mobilization in primary human lung fibroblasts (EC50 = 3.6 µM), which endogenously express LPA1 but not LPA2-LPA6. 1-Arachidoyl LPA (2.5 µM) also binds to the ligand-binding domain of peroxisome proliferator-activated receptor gamma (PPARgamma) in a cell-free assay. It has been found in human urine.Formal Name: (R)-2-hydroxy-3-(icosanoyloxy)propyl hydrogen phosphate, monosodium salt. Synonyms: LPA 20:4, PA(20:4/0:0), 1-Arachidoyl LPA, 1-Arachidoyl Lysophosphatidic Acid, 1-Eicosanoyl-2-hydroxy-sn-glycero-3-phosphate, 20:4 LPA. Molecular Formula: C23H46O7P . Na. Formula Weight: 488.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O=C(OC[C@@H](O)COP(O)([O-])=O)CCCCCCCCCCCCCCCCCCC.[Na+]. InChi Code: InChI=1S/C23H47O7P.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(25)29-20-22(24)21-30-31(26,27)28,/h22,24H,2-21H2,1H3,(H2,26,27,28),/q,+1/p-1/t22-,/m1./s1. InChi Key: AEAFHZIRTFLOQF-VZYDHVRKSA-M.