NIAD-4

NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-beta (Abeta) plaques (Ki = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red emission occurring upon binding to Abeta.Formal Name: 2-[[5'-(4-hydroxyphenyl)[2,2'-bithiophen]-5-yl]-methylene]-propanedinitrile. CAS Number: 868592-56-7. Molecular Formula: C18H10N2OS2. Formula Weight: 334.4. Purity: >98%. Emission: 625 nm. Excitation: 475 nm. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/mL, DMSO: 25 mg/mL, DMSO:PBS(pH 7.2) (1:2): 0.3 mg/mL, Ethanol: 0.2 mg/mL. lambdamax: 257, 300, 467 nm. SMILES: OC1=CC=C(C2=CC=C(C3=CC=C(/C=C(C#N)/C#N)S3)S2)C=C1. InChi Code: InChI=1S/C18H10N2OS2/c19-10-12(11-20)9-15-5-6-17(22-15)18-8-7-16(23-18)13-1-3-14(21)4-2-13/h1-9,21H. InChi Key: KLFRZDOQQDHVSS-UHFFFAOYSA-N.