Zonisamide

Description: Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate. Target: Carbonic Anhydrase, Calcium Channel, Sodium Channel. Smiles: C(S(N)(=O)=O)C=1C=2C(ON1)=CC=CC2. References: Sonsalla PK, et al. Exp Neurol, 2010, 221(2), 329-334.