Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide (Cay-24183) by GC- or LC-MS. Zonisamide is an antiepileptic agent. It selectively inhibits the repeated firing of sodium channels (IC50 = 2 µg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 µg/ml. In rat cerebral cortex neurons, zonisamide (1-1,000 µM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current. Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively. In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine (Cay-21992), but not homovanillic acid (HVA, Cay-27307) or dihydroxyphenyl acetic acid (DOPAC, Cay-24912), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson's disease. Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.Formal Name: 1,2-benzisoxazole-3-13C-3-methane-13C-sulfonamide-15N. CAS Number: 1188265-58-8. Molecular Formula: C6[13C]2H8N[15N]O3S. Formula Weight: 215.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: [15NH2]S([13CH2][13C]1=NOC2=CC=CC=C21)(=O)=O. InChi Code: InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)/i5+1,7+1,9+1. InChi Key: UBQNRHZMVUUOMG-VDWPWFDKSA-N.