Zoledronic Acid

Description: Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases. An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture. Zoledronic Acid (ZOL 446) is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis. Target: Autophagy, Rho, Apoptosis. Smiles: C(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O. References: Jagdev SP, et al. Br J Cancer, 2001, 84(8), 1126-1134.