ZLY032

ZLY032
Item number Size Datasheet Manual SDS Delivery time Quantity Price
TGM-T35816-5mg 5 mg

7 - 10 business days*

108.00€
TGM-T35816-10mg 10 mg

7 - 10 business days*

208.00€
TGM-T35816-25mg 25 mg

7 - 10 business days*

481.00€
TGM-T35816-50mg 50 mg

7 - 10 business days*

887.00€
 
Description: ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40, EC50= 68 nM in... more
Product information "ZLY032"
Description: ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40, EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor delta (PPARdelta, EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARdelta over PPARalpha and PPARgamma (EC50s = >10 µM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose. Target: Others. Smiles: C(C(O)=O)[C@H]1C=2C(=CC(OCC=3SC(=NC3C)C4=CC=C(C(F)(F)F)C=C4)=CC2)OC1. References: Li, Z., Chen, Y., Zhou, Z., et al.Discovery of first-in-class thiazole-based dual FFA1/PPARdelta agonists as potential anti-diabetic agentsEur. J. Med. Chem.164352-365(2019)
Supplier: TargetMol
Supplier-Nr: T35816

Properties

Application: Dual FFAR1 and PPARdelta agonist
MW: 449.44 D
Formula: C22H18F3NO4S

Database Information

CAS : 2314465-67-1| Matching products
KEGG ID : K04325 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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