ZLN005 (hydrochloride)

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1alpha and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 µM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1alpha and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity. This compound is the hydrochloride salt formulation of ZLN005 (Cay-14121).Formal Name: 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole, monohydrochloride. Molecular Formula: C17H18N2 . HCl. Formula Weight: 286.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 11 mg/mL, DMSO: 17 mg/mL, Ethanol: 25 mg/mL. lambdamax: 250, 303 nm. SMILES: CC(C)(C)C(C=C1)=CC=C1C2=NC3=CC=CC=C3N2.Cl. InChi Code: InChI=1S/C17H18N2.ClH/c1-17(2,3)13-10-8-12(9-11-13)16-18-14-6-4-5-7-15(14)19-16,/h4-11H,1-3H3,(H,18,19),1H. InChi Key: PRHDHWLJRJJOED-UHFFFAOYSA-N.