ZK 824859

ZK 824859 is an inhibitor of urokinase-type plasminogen activator (uPA, IC50s = 79 and 410 nM for the human and mouse proteins, respectively). It is selective for human uPA over human tissue-type plasminogen activator (tPA) and plasmin (IC50s = 1,580 and 1,330 nM, respectively) but not selective for mouse uPA over mouse tPA and plasmin (IC50s = 910 and 1,600 nM, respectively). ZK 824859 (25 or 50 mg/kg per day) reduces the incidence of limb weakness and paralysis in mice in a model of experimental autoimmune encephalomyelitis (EAE).Formal Name: 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-butanoic acid. CAS Number: 2254001-81-3. Molecular Formula: C22H20F2N2O4. Formula Weight: 414.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: NCC1=CC=CC(C2=CC(OC3=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N3)=CC=C2)=C1. InChi Code: InChI=1S/C22H20F2N2O4/c1-2-19(22(27)28)30-21-18(24)11-17(23)20(26-21)29-16-8-4-7-15(10-16)14-6-3-5-13(9-14)12-25/h3-11,19H,2,12,25H2,1H3,(H,27,28)/t19-/m1/s1. InChi Key: ZDHMLADHONAIES-LJQANCHMSA-N.